Cocaine abuse is a major public health problem worldwide. In the latest national study, the number of people over the age of 12 who are current cocaine users is estimated at 1.6 million, or 0.7% of the total population.  However, a safe, efficacious pharmacological treatment for cocaine addiction remains to be discovered.  Cocaine dependence is marked by high rates of relapse, which makes it particularly difficult to treat addicts. Research in the Behavioral Neurophysiology lab (BNL) focuses broadly on understanding the neuroadaptations that occur following cocaine addiction and how they contribute to relapse.